Dr. Otto Warburg Reveals The Prime Cause of Cancer

Dr Otto Warburg - The Man Who Discovered the Prime Cause of Cancer

Dr. Otto Warburg was a German scientist who dedicated his life to researching cancer and in the 1920’s discovered it’s prime cause.  Frustrated by the lack of acceptance of his ideas, Warburg often spelled out the axiom attributed to Max Plank, “Science advances one funeral at a time.”

Cancer The Mystery Solved Series Quick-links:

  1. Cancer: The Mystery Solved
  2. Is Cancer a Genetic Disease?
  3. Dr. Otto Warburg Reveals the Prime Cause of Cancer
  4. Dr. Buteyko Reveals the Prime Cause of All Disease
  5. Tumors are Persistent, Unhealing Wounds

Like all breakthrough scientific discoveries and the scientists who’ve discovered them, they are often laughed at for decades before they are acknowledged as true.  This occurs not because their conclusions are unreasonable; it occurs because either their peers don’t understand their work or because industries profiting from the lie go to great efforts to prevent the truth from becoming widely known.  “A lie can travel halfway around the world while truth is putting on its shoes,” Mark Twain was quoted as saying.

The highly-respected Nobel Laureate Dr. Otto Warburg was one such scientist.

Dr. Otto Warburg: ‘Cancer is a Metabolic Disease’

Born in Germany in 1883, Dr. Otto Warburg was a physiologist, medical doctor and Nobel Laureate who spent much of his life devoted to researching and understanding cancer.  During the first world war he served as an officer in the elite cavalry regiment and was awarded the iron cross (first class) for bravery.[1]

Warburg stood out among his peers as one of the most highly regarded scientists in the world.  In 1931, he was the sole recipient of the nobel prize in physiology or medicine.[2]  Over the course of his career he was nominated for a nobel prize 47 times.[3]  His work was published in a number of books including his keystone volume The Metabolism of Tumours in 1931.  In a presentation to other Nobel Laureates in 1966 he made the following bold statement:[4]

“The cause of cancer is no longer a mystery; we know it occurs whenever any cell is denied 60% of its oxygen requirements.”

Warburg hypothesized that cancer cell growth was fuelled by tumor cells producing energy (adenosine triphosphate or ATP) by the anaerobic breakdown or fermentation of glucose.  Whereas healthy cells generate energy primarily through a reaction between oxygen and glucose (they “oxidize” glucose) within the mitochondria of the cell, cancer cells produce energy through the fermentation of glucose in the absence of oxygen.  The end result of energy production by healthy cells is the production of carbon dioxide, which promotes health by serving as a potent antioxidant and by shuttling more oxygen into cells.  Conversely, the end result of glucose fermentation by cancer cells is lactic acid or lactate, which can be consistently found in high levels within the bodies of people with cancer.

“Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by fermentation of sugar.”
– Dr. Otto Warburg

Dr. Warburg made it clear that the root cause of cancer was oxygen deficiency caused by malfunctioning mitochondria.  But as highly-regarded as he was by his peers, none of them took his finding seriously: It was almost as if they saw him as an otherwise brilliant scientist with a single flaw.  Frustrated by the lack of acceptance of his ideas, Warburg often spelled out the axiom attributed to Max Plank, “Science advances one funeral at a time.”[5]

It wasn’t until the past decade that Warburg’s work has begun experiencing a resurgence, and publishing activity of scientific papers worldwide has begun to soar.  It took almost 100 years, but scientists are finally beginning to acknowledge that Warburg had been right all along.

“All normal cells have an absolute requirement for oxygen, but cancer cells can live without oxygen – a rule without exception.”
– Dr. Otto Warburg

Modern Research Validates Otto Warburg’s Discovery

When a cell is deprived of oxygen, it undergoes a metabolic shift – from the oxidation of glucose to glucose fermentation – aptly titled The Warburg EffectThe second this shift in metabolism occurs is the moment it becomes a cancer cell.  It’s also the moment that genomic instability and mutations begin to occur.

Warburg knew it – and in recent years, a myriad of other scientific studies from across the world have verified it: Only after a cell is deprived of oxygen (hypoxia) do genetic mutations begin to occur, or said differently, hypoxia is the primary driver of genetic mutations.[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]

Carlos Sonnenschein and Anna Soto of Tufts University School of Medicine in Boston, Massachussets wrote in a study they published in 2000, “We argue that it is necessary to abandon the somatic mutation theory.”[24]  That was 17 years ago, and the medical establishment is still pushing the outdated, fairytale (yet profitable) story that cancer is caused by genetic mutations.  (I hope this inspires you to stop believing in authority and to question everything you’re told.)

Thanks to the research of Dr. Otto Warburg and many others, we now know that cancer is a metabolic disease caused by oxygen deficiency – not a genetic disease caused by genomic mutations.

Homing in on The Root Cause of All Disease

To broaden our understanding of the effects of hypoxia on cells, Dr. Arthur C. Guyton – author of one of the most widely used medical textbooks in the world, The Textbook of Medical Physiology – made this extraordinary statement in 1976:

“All chronic pain, suffering and diseases are caused from a lack of oxygen at the cell level.”
-Dr. Arthur C. Guyton

Suddenly, our quest to discover how to prevent and cure cancer, we’ve not only identified cancer’s prime cause, but in doing so we’ve come face-to-face with the possibility that what cures cancer, cures all diseases.  What this means is that cancer and all diseases are metabolic in nature, and remarkably, all can be reversed by restoring the efficient use of oxygen.

Summary

  • Dr. Otto Warburg was a Nobel Prize-winning scientist who was nominated for the award 47 times in his career.
  • Cancer is a disease of damaged cellular metabolism, characterized by a shift from the oxidation of sugar to the fermentation of sugar.
  • Genetic mutations seen in cancer cells are the result of damaged mitochondrial function, not the cause.
  • Healthy cells produce carbon dioxide while cancer cells produce lactic acid.
  • The author of one of the most widely used oncology textbooks in the world hypothesized that ALL diseases have the same cause of cancer – oxygen deficiency.
  • Cancer, and all diseases, are metabolic in nature, and all can be corrected by restoring the efficient use of oxygen.

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References

  1. Krebs, H. A. (1972). “Otto Heinrich Warburg 1883-1970”. Biographical Memoirs of Fellows of the Royal Society. 18: 628–699.
  2. NobelPrize.org. The Nobel Prize in Physiology or Medicine 1931. Accessed October 15, 2017.
  3. https://www.nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-nomination.html
  4. Francis, R. 2011. Never Fear Cancer Again: How to Prevent and Reverse Cancer. HCI. 384ps. (Link to book)
  5. van Wijk, Roeland (2014). Light in Shaping Life: Biophotons in Biology and Medicine. p. 86. (Link to book)
  6. Luoto KR, Kumareswaran R, Bristow RG. Tumor hypoxia as a driving force in genetic instability. Genome Integr. 2013;4(1):5.
  7. Kumareswaran R, Ludkovski O, Meng A, Sykes J, Pintilie M, Bristow RG. Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability. J Cell Sci. 2012;125(Pt 1):189-99.
  8. Taiakina D, Dal pra A, Bristow RG. Intratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancer. Adv Exp Med Biol. 2014;772:189-204.
  9. Scanlon SE, Glazer PM. Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment. DNA Repair (Amst). 2015;32:180-9.
  10. Chan N, Koch CJ, Bristow RG. Tumor hypoxia as a modifier of DNA strand break and cross-link repair. Curr Mol Med. 2009;9(4):401-10.
  11. Chan N, Ali M, Mccallum GP, et al. Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells. Mol Cancer Res. 2014;12(10):1407-15.
  12. Meng AX, Jalali F, Cuddihy A, et al. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol. 2005;76(2):168-76.
  13. Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 2008;8(3):180-92.
  14. Chan N, Bristow RG. “Contextual” synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair. Clin Cancer Res. 2010;16(18):4553-60.
  15. Bindra RS, Crosby ME, Glazer PM. Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev. 2007;26(2):249-60.
  16. Bindra RS, Schaffer PJ, Meng A, et al. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol. 2004;24(19):8504-18.
  17. Bindra RS, Schaffer PJ, Meng A, et al. Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Ann N Y Acad Sci. 2005;1059:184-95.
  18. Chan N, Pires IM, Bencokova Z, et al. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res. 2010;70(20):8045-54.
  19. Chan N, Milosevic M, Bristow RG. Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies. Future Oncol. 2007;3(3):329-41.
  20. Bindra RS, Glazer PM. Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res. 2005;569(1-2):75-85.
  21. Wigerup C, Påhlman S, Bexell D. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacol Ther. 2016;164:152-69.
  22. Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE. Hypoxia and DNA repair. Yale J Biol Med. 2013;86(4):443-51.
  23. Yoo YG, Hayashi M, Christensen J, Huang LE. An essential role of the HIF-1alpha-c-Myc axis in malignant progression. Ann N Y Acad Sci. 2009;1177:198-204.
  24. Sonnenschein C, Soto AM. Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog. 2000;29(4):205-11.

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